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Latest Articles on Ebola

  • Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production Sun, 23 Jan 2022 06:00:00 -0500
    Ebola virus (EBOV) is one of the deadliest infective agents whose lethality is linked to the ability to efficiently bypass the host's innate antiviral response. EBOV multifunctional protein VP35 plays a major role in viral replication both as polymerase cofactor and interferon (IFN) antagonist. By hiding the non-self 5'-ppp dsRNA from the cellular receptor RIG-I, VP35 prevents its activation and inhibits IFN-β production. Blocking VP35-dsRNA interaction and IFN-β suppression is a validated drug...
  • Ebola Virus GP Activates Endothelial Cells via Host Cytoskeletal Signaling Factors Sat, 22 Jan 2022 06:00:00 -0500
    Ebola virus disease (EVD) is a lethal disease caused by the highly pathogenic Ebola virus (EBOV), and its major symptoms in severe cases include vascular leakage and hemorrhage. These symptoms are caused by abnormal activation and disruption of endothelial cells (ECs) whose mediators include EBOV glycoprotein (GP) without the need for viral replication. However, the detailed molecular mechanisms underlying virus-host interactions remain largely unknown. Here, we show that EBOV-like particles...
  • Activity of Galidesivir in a Hamster Model of SARS-CoV-2 Sat, 22 Jan 2022 06:00:00 -0500
    Coronavirus disease 2019 (COVID-19) has claimed the lives of millions of people worldwide since it first emerged. The impact of the COVID-19 pandemic on public health and the global economy has highlighted the medical need for the development of broadly acting interventions against emerging viral threats. Galidesivir is a broad-spectrum antiviral compound with demonstrated in vitro and in vivo efficacy against several RNA viruses of public health concern, including those causing yellow fever,...
  • Association between oral antimalarial medication administration and mortality among patients with Ebola virus disease: a multisite cohort study Fri, 21 Jan 2022 06:00:00 -0500
    CONCLUSION: Early oral antimalarial treatment in an EVD outbreak was associated with reduced mortality. Further study is warranted to investigate this association between early oral antimalarial treatment and mortality in EVD patients.
  • The ring vaccination trial design for the estimation of vaccine efficacy and effectiveness during infectious disease outbreaks Fri, 21 Jan 2022 06:00:00 -0500
    The ring vaccination trial is a recently developed approach for evaluating the efficacy and effectiveness of vaccines, modeled after the surveillance and containment strategy of ring vaccination. Contacts and contacts of contacts of a newly identified disease case form a ring, and these rings are randomized as part of a cluster-randomized trial or with individual randomization within rings. Key advantages of the design include its flexibility to follow the epidemic as it progresses and the...
  • TRIPS to Where? A Narrative Review of the Empirical Literature on Intellectual Property Licensing Models to Promote Global Diffusion of Essential Medicines Fri, 21 Jan 2022 06:00:00 -0500
    Governed through the World Trade Organization Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) since 1995, the current medical R&D system requires significant trade-offs between innovation and high monopoly prices for patented drugs that restrict patient access to medicines. Since its implementation, few amendments have been made to the original TRIPS agreement to allow low- and middle-income countries (LMICs) to facilitate access by generic manufacturers through...
  • HIV-1 trans-Infection Mediated by DCs: The Tip of the Iceberg of Cell-to-Cell Viral Transmission Fri, 21 Jan 2022 06:00:00 -0500
    HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 particles. Dendritic cells (DCs) are the most potent antigen presenting cells that initiate antiviral immune responses, but are also the cells with highest capacity to transfer HIV-1. This mechanism, known as trans-infection, relies on the capacity of...
  • Scientometric Analysis of Public Health Emergencies: 1994-2020 Fri, 21 Jan 2022 06:00:00 -0500
    The purpose of this paper is to summarize the research hotspots and frontiers in the field of public health emergencies (PHE) between 1994-2020 through the scientometric analysis method. In total, 2247 literature works retrieved from the Web of Science core database were analyzed by CiteSpace software, and the results were displayed in knowledge mapping. The overall characteristics analysis showed that the number of publications and authors in the field of PHE kept an upward trend during the...
  • Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens Thu, 20 Jan 2022 06:00:00 -0500
    Successful control of emerging infectious diseases requires accelerated development of fast, affordable, and accessible assays for wide implementation at a high frequency. This paper presents a design for an in-solution assay pipeline, featuring nanobody-functionalized nanoparticles for rapid, electronic detection (Nano2RED) of Ebola and COVID-19 antigens. Synthetic nanobody binders with high affinity, specificity, and stability are selected from a combinatorial library and site-specifically...
  • Synthesis and biological application of glyco- and peptide derivatives of fullerene C60 Thu, 20 Jan 2022 06:00:00 -0500
    Fullerenes have attracted considerable attention for their possible use in human therapy. Pure C(60) is soluble only in some organic solvents, but this could be overcome by chemical modifications. This review investigates the derivatization strategies and biological applications of fullerene C(60) by using polar "active" molecules as sugars and amino acids/peptides that allow the increase of solubility in water. The effect of glycosylation on biological activity of fullerene can be divided in...