Ebola Virus Net is the web resource for anyone interested in ebola. Ebola (Ebola hemorrhagic fever), is a severe, often fatal disease in humans and nonhuman primates such as monkeys, gorillas, and chimpanzees. Ebola is a rare and deadly disease caused by infection with a virus of the family Filoviridae, genus Ebolavirus. There are five identified Ebolavirus species, four of which have caused disease in humans. Ebola is found in several African countries. The first Ebola species was discovered in 1976 near the Ebola River in the Democratic Republic of the Congo. Since then, outbreaks have appeared sporadically in Africa. The largest outbreak to date was the epidemic in West Africa, which occurred from December 2013, to January 2016, with 28,646 cases and 11,323 deaths. Other outbreaks in Africa began in the Democratic Republic of the Congo in May 2017 and 2018. In July 2019, the World Health Organization declared the Congo Ebola outbreak a world health emergency.
When an infection does occur in humans, the virus can be spread to others through direct contact with the blood or body fluids of a person who is sick with Ebola, or through contact with objects that have been contaminated with the blood or body fluids of an infected person. Until recent, no vaccines were effective. In December 2016, Ebola was found to be 70–100% prevented by rVSV-ZEBOV vaccine, making it the first proven vaccine against the disease. More than 100,000 people have been vaccinated against Ebola as of 2019.
The objectives of Ebola Virus Net are to be the public and professional information resource for ebola and to serve as a network in the exchange of information and news related to ebola.
- Ebola virus can lie low and reactivate after years in human survivors - Nature.com
Wed, 15 Sep 2021 15:08 GMT
- First Ebola Case in 25 Years Confirmed on Ivory Coast - Everyday Health
Fri, 20 Aug 2021 07:00 GMT
- 'Ebola is defeated', says Congolese professor who discovered virus - FRANCE 24
Fri, 17 Sep 2021 07:26 GMT
- New test finds no evidence of Ebola virus in Cote d'Ivoire case - WHO | Regional Office for Africa
Tue, 31 Aug 2021 07:00 GMT
- Encouraging data from Johnson & Johnson on Ebola vaccine - BioPharma-Reporter.com
Tue, 14 Sep 2021 15:39 GMT
- West Africa: Ebola outbreak - International Federation of Red Cross and Red Crescent Societies
Mon, 06 Sep 2021 13:49 GMT
- Two-dose J&J Ebola vaccine gives strong immune response - CIDRAP
Wed, 15 Sep 2021 16:12 GMT
- Ebola vaccine regimen generates strong immune response in children and adults in a clinical trial in Sierra Leone - Science Daily
Mon, 13 Sep 2021 23:37 GMT
- Ivory Coast’s first Ebola patient in more than 25 years declared ‘cured’ - FRANCE 24 English
Wed, 25 Aug 2021 07:00 GMT
- Ebola Misdiagnosis Causes Jittery Ivory Coast to Vaccinate 4000 - Bloomberg
Thu, 02 Sep 2021 07:00 GMT
- Ivory Coast says first Ebola patient since 1994 has recovered - Africanews English
Fri, 27 Aug 2021 07:00 GMT
- Feared and forgotten: Congo's Ebola orphans work to survive - Sight Magazine
Fri, 17 Sep 2021 01:45 GMT
- Temporal evolution of the humoral antibody response after Ebola virus disease in Guinea: a 60-month observational prospective cohort study - The Lancet
Fri, 03 Sep 2021 07:00 GMT
- Congo's Ebola orphans work to survive amid trauma and stigma - Thomson Reuters Foundation
Thu, 16 Sep 2021 09:07 GMT
- Burkina Faso reports suspected Ebola case - Africa Times
Mon, 23 Aug 2021 07:00 GMT
- PRO/AH/EDR> Ebola update (44): Burkina Faso ex Cote d'Ivoire, 2nd case, NOT
Mon, 30 Aug 2021 11:01:25 -0400
Ebola -- Burkina Faso
On 22 Aug 2021, the Ministry of Health informed the population of the admission to the Medical Emergencies of the Bogodogo University Hospital (CHU-B) of a 22-year-old patient who had stayed in the Republic of [Cote d'Ivoire]. The diagnostic procedure consisted of sampling analysis at the National Reference Laboratory for Viral Haemorrhagic Fever (LNR-FHV at the Muraz Centre) and the Pasteur Institute of Dakar for confirmation. The results obtained make it possible to permanently rule out
- Comparison of machine learning methods for estimating case fatality ratios: An Ebola outbreak simulation study Wed, 15 Sep 2021 06:00:00 -0400
CONCLUSION: ML methods could reduce bias and increase the precision in CFR estimates at low levels of missingness. However, no method is robust to high percentages of missingness. Thus, a datacentric approach is recommended in outbreak settings-patient survival outcome data should be prioritised for collection and random-sample follow-ups should be implemented to ascertain missing outcomes.
- Low-Valent Calixarene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN Wed, 15 Sep 2021 06:00:00 -0400
In addition to a variety of viral-glycoprotein receptors (e.g., heparan sulfate, Niemann-Pick C1, etc.), dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), from the C-type lectin receptor family, plays one of the most important pathogenic functions for a wide range of viruses (e.g., Ebola, human cytomegalovirus (HCMV), HIV-1, severe acute respiratory syndrome coronavirus 2, etc.) that invade host cells before replication; thus, its inhibition represents a...
- Immunophenotyping and transcriptional profiling of human plasmablasts in dengue Wed, 15 Sep 2021 06:00:00 -0400
Plasmablasts represent a specialized class of antibody secreting effector B cell population that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections leading to viral hemorrhagic fevers such as dengue or ebola. To gain a detailed understanding of the human plasmablast responses beyond antibody expression, here we performed immunophenotyping and RNA seq analysis of the...
- Third-generation smallpox vaccine strain-based recombinant vaccines for viral hemorrhagic fevers Wed, 15 Sep 2021 06:00:00 -0400
Vaccinia virus has been used as a smallpox vaccine. Now that smallpox has been eradicated, the vaccinia virus is expected to be used as a bioterrorism countermeasure and a recombinant vaccine vector for other infectious diseases, such as viral hemorrhagic fevers. Many vaccinia virus strains were used as smallpox vaccines in the smallpox eradication campaign coordinated by the World Health Organization. These strains can be classified into generations, according to the history of improving...
- Optimization of single dose VSV-based COVID-19 vaccination in hamsters Tue, 14 Sep 2021 06:00:00 -0400
The ongoing COVID-19 pandemic has resulted in global effects on human health, economic stability, and social norms. The emergence of viral variants raises concerns about the efficacy of existing vaccines and highlights the continued need the for the development of efficient, fast-acting, and cost-effective vaccines. Here, we demonstrate the immunogenicity and protective efficacy of two vesicular stomatitis virus (VSV)-based vaccines encoding the SARS-CoV-2 spike protein either alone (VSV-SARS2)...
- Bats and viruses: a death-defying friendship Tue, 14 Sep 2021 06:00:00 -0400
Bats have a primeval evolutionary origin and have adopted various survival methods. They have played a central role in the emergence of various viral diseases. The sustenance of a plethora of virus species inside them has been an earnest area of study. This review explains how the evolution of viruses in bats has been linked to their metabolic pathways, flight abilities, reproductive abilities and colonization behaviors. The utilization of host immune response by DNA and RNA viruses is a...
- Knowledge, Attitude and Practice of Sudanese Health Care Providers toward Ebola Virus Outbreak Mon, 13 Sep 2021 06:00:00 -0400
Ebola virus disease (EVD) is a highly contagious and fatal disease in humans. Healthcare providers (HCPs) are often at the frontline of epidemics and can thus be in jeopardy of contracting EVD. Sudan is at a great risk of an EVD outbreak, as it borders countries that experienced EVD outbreaks. It is therefore imperative in Sudan to assess the HCPs' awareness and knowledge, attitude, and practice (KAP) about EVD for its control and man-agement and for preparedness. A KAP survey was conducted...
- Framework for creating an incident command center during crises Mon, 13 Sep 2021 06:00:00 -0400
The Hospital Incident Command System (HICS) is an incident management system specific to hospitals based on the principles of Incident Command System (ICS), and it includes prevention, protection, mitigation, response, and recovery. It plays a crucial role in effective and timely response during the periods of disasters, mass casualties, and public health emergencies. In recent times, hospitals have used a customized HICS structure to coordinate effective responses to public health problems such...
- The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa Fri, 10 Sep 2021 06:00:00 -0400
CONCLUSION: These findings point to a need to perform further research studies aimed at fulfilling these knowledge gaps and address current shortcomings in the provision of care for those living with HIV in Liberia.
- Time-series analyses of directional sequence changes in SARS-CoV-2 genomes and an efficient search method for candidates for advantageous mutations for growth in human cells Wed, 08 Sep 2021 06:00:00 -0400
We first conducted time-series analysis of mono- and dinucleotide composition for over 10,000 SARS-CoV-2 genomes, as well as over 1500 Zaire ebolavirus genomes, and found clear time-series changes in the compositions on a monthly basis, which should reflect viral adaptations for efficient growth in human cells. We next developed a sequence alignment free method that extensively searches for advantageous mutations and rank them in an increase level for their intrapopulation frequency. Time-series...