Ebola Virus Net is the web resource for anyone interested in ebola. Ebola (Ebola hemorrhagic fever), is a severe, often fatal disease in humans and nonhuman primates such as monkeys, gorillas, and chimpanzees. Ebola is a rare and deadly disease caused by infection with a virus of the family Filoviridae, genus Ebolavirus. There are five identified Ebolavirus species, four of which have caused disease in humans. Ebola is found in several African countries. The first Ebola species was discovered in 1976 near the Ebola River in the Democratic Republic of the Congo. Since then, outbreaks have appeared sporadically in Africa. The largest outbreak to date was the epidemic in West Africa, which occurred from December 2013, to January 2016, with 28,646 cases and 11,323 deaths. Other outbreaks in Africa began in the Democratic Republic of the Congo in May 2017 and 2018. In July 2019, the World Health Organization declared the Congo Ebola outbreak a world health emergency.

When an infection does occur in humans, the virus can be spread to others through direct contact with the blood or body fluids of a person who is sick with Ebola, or through contact with objects that have been contaminated with the blood or body fluids of an infected person. Until recent, no vaccines were effective. In December 2016, Ebola was found to be 70–100% prevented by rVSV-ZEBOV vaccine, making it the first proven vaccine against the disease. More than 100,000 people have been vaccinated against Ebola as of 2019.

The objectives of Ebola Virus Net are to be the public and professional information resource for ebola and to serve as a network in the exchange of information and news related to ebola.

• Uncovered: Crucial insight into how Ebola virus evades our immune defenses - EurekAlert
  Thu, 24 Jun 2021 18:03 GMT
• Leaving a legacy after Ebola in Guinea - Guinea - ReliefWeb
  Thu, 24 Jun 2021 08:07 GMT
• 10 Key Pillars to an Effective Ebola Response - Contagionlive.com - Contagionlive.com
  Wed, 23 Jun 2021 13:07 GMT
• Guinea declares end to Ebola outbreak that killed 12 - Reuters
  Sat, 19 Jun 2021 12:39 GMT
• Outbreak Brief 15: Ebola virus disease (EVD) Outbreak – Africa CDC - africacdc.org
  Tue, 01 Jun 2021 07:00 GMT
• From years to months: How the Ebola response is getting better - Devex
  Mon, 21 Jun 2021 09:05 GMT
• Outbreak Brief 11: Ebola virus disease (EVD) Outbreak – Africa CDC - africacdc.org
  Tue, 04 May 2021 07:00 GMT
• Outbreak Brief 17: Ebola virus disease (EVD) Outbreak – Africa CDC - africacdc.org
  Tue, 15 Jun 2021 07:00 GMT
• Ebola survivors: their health struggles and how best to support them - The Conversation CA
  Thu, 27 May 2021 07:00 GMT
• How Guinea ended their second Ebola outbreak with effective healthcare response - Deseret News
  Tue, 22 Jun 2021 15:00 GMT
• Outbreak Brief 16: Ebola virus disease (EVD) Outbreak – Africa CDC - africacdc.org
  Tue, 08 Jun 2021 07:00 GMT
• UNICEF Guinea Ebola Situation Report No. 7: 14 May - 1 June 2021 - Guinea - ReliefWeb
  Mon, 07 Jun 2021 16:22 GMT
• What we know about 2014 Ebola outbreak, how is the virus transmitted & its origin - ThePrint
  Thu, 27 May 2021 07:00 GMT
• Federal Circuit Affirms Ebola Cost Recovery Case With Potential COVID Implications - Government, Public Sector - United States - Mondaq News Alerts
  Tue, 22 Jun 2021 13:31 GMT
• Tips to Maximize Contractor Recoveries for Public Health-Related Claims: Lessons from Pernix Serka and the Ebola Crisis - JD Supra
  Thu, 24 Jun 2021 18:31 GMT

• PRO/AH/EDR> Ebola update (36): Guinea
  Mon, 21 Jun 2021 20:36:12 -0400
  Ebola -- Guinea
  The Ebola outbreak that emerged in Guinea in mid-February 2021 was declared over today [19 Jun 2021]. It was the 1st time the disease resurfaced in the country since the deadly outbreak in West Africa that ended in 2016.
  Guinean health authorities declared the outbreak on 14 Feb 2021 after 3 cases were detected in Gouecke, a rural community in the southern N'zerekore prefecture, the same region where the 2014-2016 outbreak 1st emerged before spreading into neighbouring Liberia and Sierra

• Antagonism of STAT3 signalling by Ebola virus Thu, 24 Jun 2021 06:00:00 -0400
  Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important to Ebola virus (EBOV) haemorrhagic fever, is poorly defined. We report that EBOV potently inhibits STAT3 responses to interleukin-6 family cytokines, and that this is mediated by the interferon-antagonist VP24. Mechanistic analysis indicates that...
• The 2021 Ebola virus outbreak in Guinea: Mistrust and the shortcomings of outbreak surveillance Thu, 24 Jun 2021 06:00:00 -0400
  No abstract
• Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion Thu, 24 Jun 2021 06:00:00 -0400
  CONCLUSIONS: This distinction between the Δ19-S variant and WT-S protein may have downstream implications for studies that utilize pseudovirus-based entry assays. Additionally, this study suggest that spike protein expressed by vaccines may affect different ACE2-expressing host cells after SARS-CoV-2 vaccine administration. The long-term effects of these vaccines should be monitored carefully. Δ19-S mRNA may represent a safer mRNA vaccine design in the future.
• Why does the Ebola virus epidemic continue to plague the Democratic Republic of the Congo? Wed, 23 Jun 2021 06:00:00 -0400
  Why does the ebola virus epidemic continue to plague the democratic republic Of the congo?Ebola virus disease outbreak continues in North Kivu and Ituri provinces in the Democratic Republic of the Congo, despite a marked improvement in management of medical care and prevention of the disease. Since August 2018, the disease has been evolving in a complex epidemic field, forgotten by the international press. In the sensitive geopolitic context with this area of armed conflicts more than 20 years,...
• Identification and characterization of defective viral genomes in Ebola virus infected rhesus macaques Wed, 23 Jun 2021 06:00:00 -0400
  Ebola virus (EBOV), of the family Filoviridae, is an RNA virus that can cause hemorrhagic fever with a high mortality rate. Defective viral genomes (DVGs) are truncated genomes that have been observed during multiple RNA virus infections, including in vitro EBOV infection, and have previously been associated with viral persistence and immunostimulatory activity. As DVGs have been detected in cells persistently infected with EBOV, we hypothesized that DVGs may also accumulate during viral...
• The Application of a Safe Neutralization Assay for Ebola Virus Using Lentivirus-Based Pseudotyped Virus Mon, 21 Jun 2021 06:00:00 -0400
  No abstract
• Microneedle-based devices for point-of-care infectious disease diagnostics Mon, 21 Jun 2021 06:00:00 -0400
  Recent infectious disease outbreaks, such as COVID-19 and Ebola, have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission. Successful diagnostic strategies critically depend on the efficiency of biological sampling and timely analysis. However, current diagnostic techniques are invasive/intrusive and present a severe bottleneck by requiring specialist equipment and trained personnel. Moreover, centralised test facilities are poorly accessible and the...
• Drawing Parallels Among Past Public Health Crises and COVID-19 Fri, 18 Jun 2021 06:00:00 -0400
  In the early stages of the COVID-19 pandemic, there were shortages of personal protective equipment (PPE) and healthcare personnel across severely affected regions. Along with a lack of testing, these shortages delayed surveillance, and possible containment of the virus. The pandemic also took unprecedented tolls on the mental health of many healthcare workers who treated and witnessed the deaths of critically ill patients. To address these effects and prepare for a potential second wave, a...
• SARS-CoV-2 variants and the so-called resistance to vaccines Thu, 17 Jun 2021 06:00:00 -0400
  RNA viruses (except retroviruses) replicate by the action of an RNA-dependent RNA polymerase, which lacks a proofreading exonuclease and, consequently, errors may occur in each replication giving place to viral mutants. Depending on their fitness, these mutants either become extinct or thrive, spawning variants that escape the immune system. The most important SARS-CoV-2 mutations are those that alter the amino acid sequence in the viral S protein because this protein holds the key for the virus...
• Reported health and social consequences of the COVID-19 pandemic on vulnerable populations and implemented solutions in six West African countries: A media content analysis Wed, 16 Jun 2021 06:00:00 -0400
  Coronavirus has spread worldwide with over 140 million cases and resulting in more than 3 million deaths between November 2019 to April 2021, threatening the socio-economic and psychosocial stability of many families and communities. There has been limited research to understand the consequences of COVID-19 on vulnerable populations in West Africa, and whether such consequences differ by countries' previous experience with Ebola. Using a media analysis of leading online news sources, this study...